To be or not to B27 positive: implications for the phenotypes of axial spondyloarthritis outcomes. Data from a large multiracial cohort from the Brazilian Registry of Spondyloarthritis.
Gustavo Gomes ResendeCarla Goncalves Schahin SaadClaudia Diniz Lopes MarquesSandra Lúcia Euzébio RibeiroMaria Bernadete Renoldi de Oliveira GaviMichel Alexandre YazbekAdriana de Oliveira MarinhoRita de Cássia MeninManuella Lima Gomes OchtropAndressa Miozzo SoaresNara Gualberto CavalcantiJamille Nascimento CarneiroGlaucio Ricardo Werner de CastroJosé Mauro Carneiro FernandesElziane da Cruz Ribeiro E SouzaCorina Quental de Menezes AlvarengaRejane Maria Rodrigues de Abreu VieiraNatalia Pereira MachadoAntônio Carlos XimenesMorgana Ohira GazzetaCleandro Pires de AlbuquerqueThelma Larocca SkareMauro Waldemar KeisermanCharles Lubianca KohemGabriel Sarkis BenaconVítor Florêncio Santos RochaRicardo da Cruz LageOlivio Brito MalheiroRywka Tenenbaum Medeiros GolebiovskiThauana Luiza OliveiraRuben Horst DuqueAna Carolina LondeMarcelo de Medeiros PinheiroPercival Degrava Sampaio-BarrosPublished in: Advances in rheumatology (London, England) (2024)
Our data showed that HLA-B27 positivity was associated with a classic axSpA pattern quite similar to that of Caucasian axSpA patients around the world. Furthermore, its absence was associated with peripheral manifestations and worse outcomes, suggesting a relevant phenotypic difference in a highly miscegenated population.