Epigenome-Wide Association Studies of COPD and Lung Function: A Systematic Review.
Sandra Casas-RecasensRaisa CassimNúria MendozaAlvar AgustíCaroline LodgeShuai LiShyamali C DharmageDavid J MartinoShyamali C DharmageRosa FanerPublished in: American journal of respiratory and critical care medicine (2024)
There is high heterogeneity across published COPD/lung function EWAS studies. A few genes (n=123; 2.6%) were replicated in blood and respiratory samples, suggesting that blood can recapitulate some changes in respiratory tissues. These findings have implications for future research.