FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer.

Zhiyuan ZhouBin ZhangYue DengSuke DengJie LiWenwen WeiYijun WangJiacheng WangZishan FengMengjie CheXiao YangJingshu MengYan LiYan HuYajie SunLu WenFang HuangYuhan ShengChao WanKunyu Yang

Published in: Journal of experimental & clinical cancer research : CR (2024)

A "reader" IGF2BP2 promotes lung cancer radioresistance by forming a positive feedback loop with SLC7A5, suggesting that IGF2BP2 may be a potential therapeutic target to control radioresistance in lung cancer.

Keyphrases

pi k akt
binding protein
growth hormone
dna damage response
signaling pathway
transcription factor
cancer stem cells
cell proliferation
risk assessment
dna damage