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Single-cell multi-modal chromatin profiles revealing epigenetic regulations of cells in hepatocellular carcinoma.

Chunqing WangWaidong HuangYu ZhongXuanxuan ZouShang LiuJie LiYunfan SunKaiqian ZhouXi ChenZihao LiShanshan WangYaling HuangYinqi BaiJianhua YinXin JinShiping LiuYue YuanQiuting DengMiaomiao JiangChuanyu LiuLongqi LiuXun XuLiang Wu
Published in: Clinical and translational medicine (2024)
scCPA-Tag offers a highly efficient and high throughput technique to simultaneously profile histone modification and chromatin accessibility within a single cell. scCPA-Tag enables to uncover multiple epigenetic modification features of cellular compositions within tumor tissues. scCPA-Tag facilitates the exploration of the epigenetic landscapes of heterogeneous cell types and provides the mechanisms governing gene expression regulation.
Keyphrases
  • gene expression
  • single cell
  • dna methylation
  • high throughput
  • highly efficient
  • rna seq
  • genome wide
  • induced apoptosis
  • cell cycle arrest
  • dna damage
  • transcription factor
  • cell therapy
  • signaling pathway
  • pi k akt