A Validation Study on IDO Immune Biomarkers for Survival Prediction in Non-Small Cell Lung Cancer: Radiation Dose Fractionation Effect in Early-Stage Disease.

Weili WangLei HuangJian-Yue JinWenhu PiSusannah G EllsworthShruti JollyAndrew L MellorMitchell MachtayFeng-Ming Spring Kong

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

This study validated that elevated IDO activity correlated with worse survival outcomes in patients with early-stage NSCLC treated with definitive RT. Hypofractionated SBRT may have less immunosuppressive effect than 3DCRT, as measured by IDO.

Keyphrases

early stage
radiation therapy
small cell lung cancer
sentinel lymph node
squamous cell carcinoma
locally advanced