Acute depletion of CTCF rewires genome-wide chromatin accessibility.

Beisi XuHong WangShaela WrightJudith HyleYang ZhangYing ShaoMingming NiuYiping FanWojciech RosikiewiczMohamed Nadhir DjekidelJunmin PengRui LuChunliang Li

Published in: Genome biology (2021)

This study highlights that CTCF loss rewires genome-wide chromatin accessibility, which plays a critical role in transcriptional regulation.

Keyphrases

genome wide
dna methylation
copy number
liver failure
gene expression
dna damage
transcription factor
intensive care unit
oxidative stress
acute respiratory distress syndrome