Thrombopoietin-dependent Myelo-megakaryopoiesis Fuels Thromboinflammation and Worsens Antibody-mediated Chronic Renal Microvascular Injury.
Mélodie DoutéAurélie SannierGuillaume EvenThi-Thu TranAhn-Tu GastonSandrine DelboscStéphane LoyauPatrick BrunevalVéronique Witko-SarsatLuc MouthonAntonino NicolettiGiuseppina CaligiuriMarc ClementPublished in: Journal of the American Society of Nephrology : JASN (2023)
TPO-skewed hematopoiesis exacerbates chronic thromboinflammation in microvessels and worsens AMCKD. TPO is both a relevant biomarker and a promising therapeutic target in humans with CKD and other chronic thromboinflammatory diseases.
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