Apolipoprotein A4 Restricts Diet-Induced Hepatic Steatosis via SREBF1-Mediated Lipogenesis and Enhances IRS-PI3K-Akt Signaling.

Cheng ChengXiao-Huan LiuJing HeJing GaoJin-Ting ZhouJing-Na FanXi JinJianbo ZhangLiao ChangZijun XiongJun YuShengbin LiXiaoming Li

Published in: Molecular nutrition & food research (2022)

ApoA4 restricts hepatic steatosis by inhibiting SREBF1-mediated lipogenesis and improves insulin sensitivity and glucose uptake via IRS-PI3K-Akt signaling in the liver. These findings indicate that ApoA4 may serve as a therapeutic target for obesity-associated NAFLD.

Keyphrases

pi k akt
signaling pathway
high fat diet induced
cell cycle arrest
cell proliferation
insulin resistance
weight loss
weight gain
blood glucose
adipose tissue
skeletal muscle