Current diagnostic tools for coronaviruses-From laboratory diagnosis to POC diagnosis for COVID-19.
Yung-Chih WangYi-Tzu LeeTing YangJun-Ren SunChing-Fen ShenChao-Min ChengPublished in: Bioengineering & translational medicine (2020)
The Coronavirus-2019 (COVID-19) pandemic has put tremendous strain on healthcare systems worldwide. It is challenging for clinicians to differentiate COVID-19 from other acute respiratory tract infections via clinical symptoms because those who are infected display a wide range of symptoms. An effective, point-of-care (POC) diagnostic tool could mitigate healthcare system strain, protect healthcare professionals, and support quarantine efforts. We believe that a POC tool can be developed that would be rapid, easy to use, and inexpensive. It could be used in the home, in resource-limited areas, and even in clinical settings. In this article, we summarize the current state of POC tools and propose an all-in-one, highly sensitive POC assay that integrates antibody detection, protein detection, and serum cytokine detection to diagnose COVID-19 infection. We believe this article will provide insight into the current state of POC diagnostics for COVID-19, and promote additional research and tool development that could be exceptionally impactful.
Keyphrases
- sars cov
- coronavirus disease
- loop mediated isothermal amplification
- healthcare
- respiratory tract
- label free
- respiratory syndrome coronavirus
- real time pcr
- liver failure
- sensitive detection
- mass spectrometry
- depressive symptoms
- high resolution
- quality improvement
- intensive care unit
- binding protein
- amino acid
- social media
- aortic dissection
- fluorescent probe
- health information
- living cells