Low serum double-stranded DNA levels are associated with higher survival rates in severe COPD patients.

Sharyn A Roodenburg Jorine E HartmanIlse A EichhornDirk-Jan Slebos Simon D Pouwels

Published in: ERJ open research (2024)

In conclusion, in a clinical cohort of 949 patients with moderate-to-severe COPD, elevated serum levels of dsDNA were associated with a higher risk of death. This study further illustrates the potential role of circulating DAMPs, such as dsDNA, in the progression of COPD. Together, the results of this study suggest that levels of circulating dsDNA might serve as an additional prognostic biomarker for survival in COPD patients.

Keyphrases

chronic obstructive pulmonary disease
end stage renal disease
lung function
newly diagnosed
chronic kidney disease
ejection fraction
prognostic factors
peritoneal dialysis
early onset
patient reported outcomes
climate change
high intensity
binding protein
air pollution
circulating tumor cells