Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment.
Cameron D OwensCamila Bonin PintoPeter MukliRafal GulejFaddi Saleh VelezSam DetwilerLauren OlayJordan R HoffmeisterZsofia SzarvasMihaly MuranyiAnna PeterfiAna Clara da C Pinaffi-LangleyCheryl AdamsJason SharpsZalan KaposztaCalin I ProdanAngelia C KirkpatrickStefano TarantiniAnna CsiszarZoltan UngvariAnn L OlsonGuangpu LiPriya BalasubramanianVeronica GalvanAndrew BauerZachary A SmithTarun W DasariShawn WhiteheadManoj R MedaptiFanny M ElahiAikaterini ThanouAndriy YabluchanskiyPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Neurovascular coupling (NVC) is impaired in mild cognitive impairment (MCI). Functional connectivity (FC) compensation mechanism is lost in MCI. Cerebrovascular endothelial extracellular vesicles (CEEVs) are increased in MCI. CEEV load strongly associates with cerebral small vessel ischemic lesions in MCI. NVC, CEEVs, and FC predict MCI diagnosis over demographic and comorbidity factors.