Thymol inhibits oral squamous cell carcinoma growth via mitochondria-mediated apoptosis.
Jorge J De La ChapaPrajjal Kanti SinghaDebbie R LeeCara B GonzalesPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2018)
Our findings provide the first evidence of thymol's novel antitumor effects against OSCC in vivo, which do not rely on TRPA1 activity. Instead, we show that thymol induces mitochondrial dysfunction and apoptosis and may be efficacious against multiple cancers.