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hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis.

Xiu CaiZhi-Yu ZhangJin-Tao YuanDickson Kofi Wiredu OcanseyQiang TuXu ZhangHui QianWen-Rong XuWei QiuFei Mao
Published in: Stem cell research & therapy (2021)
hucMSC-derived exosomes carrying miR-378a-5p inhibited NLRP3 inflammasomes and abrogated cell pyroptosis to protect against DSS-induced colitis.
Keyphrases
  • nlrp inflammasome
  • mesenchymal stem cells
  • stem cells
  • single cell
  • cell therapy
  • adipose tissue
  • bone marrow
  • ulcerative colitis