IL4-10 Fusion Protein Shows DMOAD Activity in a Rat Osteoarthritis Model.
Eefje Martine van HelvoortH M de VisserF P J G LafeberK CoeleveldS VersteegH H WeinansJ Popov-CeleketicN EijkelkampS C MastbergenPublished in: Cartilage (2021)
rIL4-10 FP showed chondroprotective and analgesic activity in a rat OA model with moderate cartilage damage, mild synovial inflammation, and pain. Future studies will need to address whether less frequent intra-articular injections, for example, with formulations with increased residence time, would also lead to DMOAD activity.