Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats.
Brian D PiccoloJames L GrahamLeslie Tabor-SimeckaChristopher E RandolphBecky MoodyMichael S RobesonPing KangRenee FoxRenny LanLindsay PackNoah WofordLaxmi YeruvaTanya LeRoithKimber L StanhopePeter J HavelPublished in: BMJ open diabetes research & care (2024)
The advancement of diabetes in UCD-T2DM rats was associated with an increase in facultative anaerobes; however, this was not explained by changes in colonocyte oxygen levels. The mechanisms underlying shifts in gut microbe populations associated with the progression of diabetes in the UCD-T2DM rat model remain to be identified.