EGFR/c-Met and mTOR signaling are predictors of survival in non-small cell lung cancer.
Zachary D CreesCaleb ShearrowLeo LinJennifer GirardKavin ArasiAayush BhoraskarJoseph BereiAdam EckburgAustin D AndersonChristian GarciaAriana MungerSunil PalaniThomas J SmithShylendra B SreenivassappaConnie VitaliOdile DavidNeelu PuriPublished in: Therapeutic advances in medical oncology (2020)
These findings suggest that increased EGFR/c-Met signaling is correlated with upregulated mTOR/S6K signaling, which may in turn be associated with shorter median survival in late-stage NSCLC.