Alendronate inhibits osteocyte apoptosis and inflammation via IL-6, inhibiting bone resorption in periapical lesions of ovariectomized rats.
R A B SilvaA P Sousa-PereiraMarília Pacífico LucisanoPriscilla Coutinho RomualdoFrancisco Wanderley Garcia de Paula E SilvaA ConsolaroL A B SilvaP Nelson-FilhoPublished in: International endodontic journal (2019)
The hypoestrogenic condition induced by OVX aggravated bone resorption, inducing the death of osteocytes and provoking larger periapical lesions. ALN treatment inhibited osteocyte apoptosis and inflammation via IL-6, inhibiting bone resorption in periapical lesions of ovariectomized rats.