Tumor-associated neutrophils suppress CD8 + T cell immunity in urothelial bladder carcinoma through the COX-2/PGE2/IDO1 Axis.

Yi Ouyang Wenlong ZhongPeiqi XuBo WangLin ZhangMeng YangJunyu ChenHong LiSheng LiXiang ChenLonghao XuZiwei OuDaqin WuYi LinChunhui WangJian Huang Tianxin Lin

Published in: British journal of cancer (2024)

TAN-secreted PGE2 upregulates IDO1, dampening T cell function in UBC. Celecoxib targeting of PGE2 synthesis represents a promising approach to enhance ICB efficacy in UBC.

Keyphrases

urinary tract
spinal cord injury
high grade
cancer therapy
drug delivery