Current treatment strategies for targeting virulence factors and biofilm formation in Acinetobacter baumannii .
Seetha Lakshmi RajangamManoj Kumar NarasimhanPublished in: Future microbiology (2024)
A higher prevalence of Acinetobacter baumannii infections and mortality rate has been reported recently in hospital-acquired infections (HAI). The biofilm-forming capability of A. baumannii makes it an extremely dangerous pathogen, especially in device-associated hospital-acquired infections (DA-HAI), thereby it resists the penetration of antibiotics. Further, the transmission of the SARS-CoV-2 virus was exacerbated in DA-HAI during the epidemic. This review specifically examines the complex interconnections between several components and genes that play a role in the biofilm formation and the development of infections. The current review provides insights into innovative treatments and therapeutic approaches to combat A. baumannii biofilm-related infections, thereby ultimately improving patient outcomes and reducing the burden of HAI.
Keyphrases
- biofilm formation
- pseudomonas aeruginosa
- acinetobacter baumannii
- candida albicans
- staphylococcus aureus
- cystic fibrosis
- sars cov
- multidrug resistant
- escherichia coli
- drug resistant
- risk factors
- healthcare
- emergency department
- coronary artery disease
- cardiovascular events
- acute care
- genome wide
- drug delivery
- electronic health record
- transcription factor
- bioinformatics analysis