Striatal Dopamine Responses to Feeding are Altered in People with Obesity.
Sarah A EisensteinKevin J BlackAmjad SamaraJonathan M KollerJulia P DunnTamara HersheySamuel KleinGordon I SmithPublished in: Obesity (Silver Spring, Md.) (2020)
People with obesity and prediabetes do not increase striatal DA release after eating a meal to satiation compared with fasting overnight and fail to inhibit DA release in response to high-calorie food stimuli after eating a meal to satiation. These data suggest that impaired DA signaling contributes to greater energy intake during meals in this population.