Differential role of PTEN in transforming growth factor β (TGF-β) effects on proliferation and migration in prostate cancer cells.

Mawiyah N Kimbrough-AllahAna C MillenaShafiq A Khan

Published in: The Prostate (2018)

We conclude that PTEN plays a role in inhibitory effects of TGF-β on cell proliferation whereas its absence may enhance TGF-β effects on activation of PI3-kinase pathway and cell migration.

Keyphrases

transforming growth factor
cell proliferation
cell migration
epithelial mesenchymal transition
pi k akt
signaling pathway
tyrosine kinase