Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas.

Holger WeishauptMatko ČančerGabriela RosénKarl O HolmbergSusana HäggqvistIgnas BunikisYiwen JiangSmitha SreedharanUlf GyllenstenOren J BecherLene UhrbomAdam Ameur Fredrik J Swartling

Published in: Neuro-oncology (2022)

Altogether, the current study has demonstrated a novel approach to tagging glioma genes via forward genetics, validating previous results, and identifying PPFIBP1 as a putative oncogene in gliomagenesis.

Keyphrases

genome wide
high throughput
copy number
genome wide identification
papillary thyroid
small molecule
dna methylation
squamous cell carcinoma
genome wide analysis
lymph node metastasis
bioinformatics analysis