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Syndrome of inappropriate secretion of antidiuretic hormone associated with angiotensin-converting enzyme inhibitor therapy in the perioperative period.

Takashin NakayamaHiroto FujisakiShintaro HiraiRuri KawauchiKyohei OgawaAyaka MitsuiKeita HiranoKazuo IsozumiTakayuki TakahashiSatoru Komatsumoto
Published in: Journal of the renin-angiotensin-aldosterone system : JRAAS (2019)
Patients treated with an ACE inhibitor can latently experience inappropriate secretion of antidiuretic hormone, and rapidly develop severe hyponatremia together with additional factors affecting water or salt homeostasis regardless of the length of the administration duration. Clinicians should monitor serum sodium levels in such patients not only just after the initiation of ACE inhibitors but also upon the appearance of those factors.
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