Intrauterine colonization with Gardnerella vaginalis and Mobiluncus mulieris induces maternal inflammation but not preterm birth in a mouse model.

Andrea Joseph Emma L LewisBriana FergusonYuxia GuanLauren AntonMichal A Elovitz

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2023)

Despite inducing an immune response, intrauterine infusion of live G. vaginalis or M. mulieris is not sufficient to induce sPTB in our mouse model. These results suggest that ascension of common vaginal microbes into the uterine cavity alone is not causative for sPTB.

Keyphrases

mouse model
preterm birth
immune response
gestational age
low birth weight
birth weight
oxidative stress
low dose
toll like receptor
body mass index
preterm infants
weight gain