Mutational Landscape and Tumor Burden Assessed by Cell-free DNA in Diffuse Large B-Cell Lymphoma in a Population-Based Study.

Alfredo Rivas-Delgado Ferran NadeuAnna EnjuanesSebastián Casanueva-Eliceiry Pablo MozasLaura MagnanoNatalia CastrejonJordina RoviraIvan DlouhySilvia MartínMiguel OsunaSonia RodríguezMarc SimóMagda PinyolTycho BaumannSílvia BeàOlga BalaguéNeus VillamorXavier SetoainElias CampoEva GinéArmondo López-Guillermo

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

In a population-based prospective DLBCL series, cfDNA resulted as an alternative source to estimate tumor burden and to determine the tumor mutational profile and genetic classification, which have prognostic implications and may contribute to a future tailored treatment.

Keyphrases

diffuse large b cell lymphoma
epstein barr virus
machine learning
genome wide
risk factors
gene expression
single cell
current status
copy number
combination therapy