SU5416 does not attenuate early RV angiogenesis in the murine chronic hypoxia PH model.

Grace L PeloquinLaura JohnstonMahendra DamarlaRachel L DamicoPaul M HassounTodd M Kolb

Published in: Respiratory research (2019)

These findings demonstrate that SU5416 directly inhibited VEGF-induced proliferation of murine cardiac endothelial cells but does not attenuate CH-PH induced RV angiogenesis or myocardial remodeling in vivo.

Keyphrases

endothelial cells
high glucose
vascular endothelial growth factor
mycobacterium tuberculosis
diabetic rats
left ventricular
drug induced
signaling pathway
heart failure