Bioavailability and Pharmacokinetics of Anisatin in Mouse Blood by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry.
Xi BaoXiajuan JiangJianshe MaLingtian WangQuan ZhouPublished in: BioMed research international (2020)
The developed UPLC-MS/MS method was successfully used for a pharmacokinetic study of oral (1 mg/kg) and intravenous (0.5 mg/kg) administration of anisatin to mice-the absolute bioavailability of anisatin in the mouse blood was 22.6%.
Keyphrases
- liquid chromatography tandem mass spectrometry
- simultaneous determination
- ms ms
- solid phase extraction
- high performance liquid chromatography
- tandem mass spectrometry
- high dose
- high fat diet induced
- high resolution
- ultra high performance liquid chromatography
- liquid chromatography
- mass spectrometry
- low dose
- adipose tissue