Bovine adapted transmissible mink encephalopathy is similar to L-BSE after passage through sheep with the VRQ/VRQ genotype but not VRQ/ARQ.

Eric CassmannSarah Jo MooreRobyn KokemullerAnne Balkema-BuschmannMartin GroschupEric NicholsonJustin J Greenlee

Published in: BMC veterinary research (2020)

Our findings provide insight on how sheep host genotype modulates strain genesis and influences interspecies transmission characteristics. Given that the transmission efficiencies of L-BSE and bTME are higher than C-BSE, coupled with previous reports of L-BSE transmission to mice expressing the human prion protein, continued monitoring for atypical BSE is advisable in order to prevent occurrences of interspecies transmission that may affect humans or other species.

Keyphrases

endothelial cells
early onset
emergency department
metabolic syndrome
electron transfer
induced pluripotent stem cells
binding protein
adverse drug