Fatal Fulminant Cerebral Edema in Six Children with SARS-CoV-2 Omicron BA.2 Infection in Taiwan.
Jainn-Jim LinYi-Fang TuShyi-Jou ChenYung-Ting KuoJeng Mei-JyMary Hsin-Ju KoCheng-Hsun ChiuPublished in: Journal of the Pediatric Infectious Diseases Society (2022)
Acute fulminant cerebral edema in children following SARS-CoV-2 infection has been rarely reported. Such patients frequently demonstrate rapid progression rapid progression and are usually fatal. In this retrospective study, we describe the detailed clinical, laboratory, and neuroimaging features of six fatal cases in Taiwan. All patients had shock initially, five showed rapid progression to multi-organ failure and disseminated intravascular coagulation, and three developed acute respiratory distress syndromes. The inflammatory biomarkers in the first 3 days, including interleukin 6, ferritin, lactate dehydrogenase and D-dimer, showed significant elevation in all cases. Hyper-inflammatory response may play a role in the pathophysiology.
Keyphrases
- end stage renal disease
- sars cov
- liver failure
- inflammatory response
- newly diagnosed
- ejection fraction
- chronic kidney disease
- young adults
- prognostic factors
- coronary artery
- peritoneal dialysis
- patient reported outcomes
- oxidative stress
- subarachnoid hemorrhage
- drug induced
- hepatitis b virus
- aortic dissection
- blood brain barrier
- toll like receptor
- lipopolysaccharide induced
- lps induced
- patient reported
- mechanical ventilation