CD300LF + microglia impede the neuroinflammation following traumatic brain injury by inhibiting STING pathway.
Zhichao LuZongheng LiuChenxing WangRui JiangZiheng WangWeiquan LiaoWei WangJianfeng ChenXingjia ZhuJingwei ZhaoQianqian LiuYang YangPeipei GongPublished in: CNS neuroscience & therapeutics (2024)
Our research indicates that CD300LF reduces neuroinflammation and promotes neurological recovery after TBI, and that microglia are integral to the protective effects of CD300LF in this context. In summary, our findings highlight CD300LF as a critical molecular regulator modulating the adverse actions of microglia following acute brain injury and propose a novel therapeutic approach to enhance outcomes for patients with TBI.
Keyphrases
- brain injury
- traumatic brain injury
- cerebral ischemia
- inflammatory response
- subarachnoid hemorrhage
- nk cells
- lipopolysaccharide induced
- spinal cord injury
- neuropathic pain
- lps induced
- liver failure
- transcription factor
- emergency department
- severe traumatic brain injury
- intensive care unit
- aortic dissection
- spinal cord
- resting state
- type diabetes
- weight loss
- drug induced
- extracorporeal membrane oxygenation
- glycemic control
- single molecule