α-Synuclein Deposition in Sympathetic Nerve Fibers in Genetic Forms of Parkinson's Disease.

Risa IsonakaDavid S GoldsteinWilliam ZhuEsther YoonDebra EhrlichAlice B SchindlerAngela D KokkinisMarya S SabirSonja W ScholzSara Bandres-CigaCornelis BlauwendraatPedro Gonzalez-AlegreGrisel LopezEllen SidranskyDerek P Narendra

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

Individuals with SNCA, DJ-1, LRRK2, or GBA mutations have substantial intraneuronal α-syn deposition in sympathetic noradrenergic nerves in skin biopsies, whereas those with biallelic PRKN mutations do not. Biallelic PRKN patients may have mildly increased α-syn deposition compared with control subjects. © 2021 International Parkinson and Movement Disorder Society.

Keyphrases

end stage renal disease
intellectual disability
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
genome wide
gene expression
soft tissue
wound healing
patient reported outcomes
copy number