Identification of novel miRNAs potentially involved in the pathogenesis of adult T-cell leukemia/lymphoma using WGCNA followed by RT-qPCR test of hub genes.

Ali ShayeghpourMohammad-Moien Forghani-RamandiSetayesh SoloukiAmin HosseiniParastoo HosseiniSara KhodayarMahsa HasaniSepehr AghajanianZeinab SiamiMohadeseh Zarei GhobadiSayed-Hamidreza Mozhgani

Published in: Infectious agents and cancer (2023)

The results of the network analysis of miRNAs and their target genes revealed the major players in the pathogenesis of ATLL. Further studies are required to confirm the role of these molecular factors and to discover their potential benefits as treatment targets and diagnostic biomarkers.

Keyphrases

bioinformatics analysis
genome wide
genome wide identification
acute myeloid leukemia
diffuse large b cell lymphoma
bone marrow
single cell
gene expression
risk assessment
single molecule
human health
transcription factor