Age, sex, and APOE gene-specific associations between dynapenic obesity and dementia in a large cohort.
Zhao YaoJie WangTianfang ZhangHongjing AiZeinab AbdelrahmanXiaohong WuDaming WangFenfen ChenZiwei ZhangXiaosheng WangZuyun LiuZuobing ChenPublished in: The journal of nutrition, health & aging (2024)
Dynapenic obesity is associated with increased risks of dementia, especially in participants under 65 years and non-ε4-carrier, suggesting the importance of managing dynapenic obesity in the prevention of cognition-related disorders.
Keyphrases
- insulin resistance
- mild cognitive impairment
- metabolic syndrome
- weight loss
- high fat diet induced
- type diabetes
- weight gain
- cognitive decline
- cognitive impairment
- multiple sclerosis
- adipose tissue
- copy number
- genome wide
- white matter
- climate change
- dna methylation
- human health
- transcription factor
- genome wide identification