All-trans retinoic acid enhances the cytotoxic effect of decitabine on myelodysplastic syndromes and acute myeloid leukaemia by activating the RARα-Nrf2 complex.

Lu WangQi ZhangLi YeXingnong YeWenli YangHua ZhangXinping ZhouYanling RenLiya MaXiang ZhangChen MeiGaixiang XuKongfei LiYingwan LuoLingxu JiangPeipei LinShuanghong ZhuWei LangYuxia WangChuying ShenYueyuan HanXiaozhen LiuHaiyang YangChenxi LuJie SunJie JinHong-Yan Tong

Published in: British journal of cancer (2022)

These results demonstrate that combining DAC and ATRA has potential for the clinical treatment of HR-MDS/AML and merits further exploration.

Keyphrases

acute myeloid leukemia
liver failure
bone marrow
oxidative stress
signaling pathway
allogeneic hematopoietic stem cell transplantation
respiratory failure
drug induced
human health
hepatitis b virus
risk assessment
acute lymphoblastic leukemia
extracorporeal membrane oxygenation
mechanical ventilation