Synthesis, ADMET Prediction, and Antitumor Profile of Phenoxyhydrazine- 1,3-thiazoles Derivatives.

Lucianna Rabelo Pessoa de SiqueiraLarissa Pelágia de Lima FerreiraGevanio Bezerra de Oliveira FilhoMarcos Victor Gregório de OliveiraAline Ferreira PintoVanessa Gouveia de Melo SilvaPaulo André Teixeira de Moraes GomesMarcos Veríssimo de Oliveira CardosoMaria de Nazaré Correia SoeiroFlaviana Alves Dos SantosMaíra Galdino da Rocha PittaJanine Siqueira NunesMoacyr Jesus Barreto de Melo RegoAna Cristina Lima Leite

Published in: Current topics in medicinal chemistry (2023)

Our study reinforced the importance of 1,3-thiazoles nuclei in antitumor activity. In addition, derivative 2b stands out against DU145 and MOLT-4 cells and could be a starting point for developing new antineoplastic agents.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
cell death
signaling pathway
cell proliferation
molecular dynamics simulations
pi k akt