Responsible genes in children with primary vesicoureteral reflux: findings from the Chinese Children Genetic Kidney Disease Database.

Jia-Lu LiuQian ShenMing-Yan WuGuang-Hua ZhuYu-Feng LiXiao-Wen WangXiao-Shan TangYun-Li BiYi-Nv GongJing ChenXiao-Yan FangYi-Hui ZhaiBing-Bing WuGuo-Min LiYu-Bo SunXiao-Jie GaoCui-Hua LiuXiao-Yun JiangSheng HaoYu-Lin KangYing-Liang GongLi-Ping RongDi LiSi WangDuan MaJia RaoHong Xunull null

Published in: World journal of pediatrics : WJP (2021)

PAX2, TNXB, GATA3 and SLIT2 were the main underlying monogenic causes and accounted for up to 46.4% of monogenic VUR. Extrarenal complications and renal function were significantly related to the findings of genetic factors in children with primary VUR. Like other types of CAKUT, several genes may be responsible for isolated VUR.

Keyphrases

genome wide
young adults
emergency department
risk factors
gene expression
copy number
bioinformatics analysis