No increased risk of postoperative adverse events in total joint replacement patients with hidradenitis suppurativa.

There is concern for increased risk of adverse events, particularly periprosthetic joint infection (PJI), following total joint replacement (TJR) in patients with hidradenitis suppurativa (HS) due to compromised skin barrier and bacterial colonization of lesions. We used TriNetX health research database to identify TJR patients with (n = 1,760) and without (n = 1,760) HS matched by age, sex, race, and risk factors for PJI. Multivariate analysis was performed and revealed that 90-day risk of PJI, re-operation, wound dehiscence, delayed wound healing, emergency room visits, and readmission were not increased among HS patients who underwent TJR. Given these findings, dermatologists and orthopaedists should not defer TJR access for HS patients, as risk of postoperative complications is not prohibitive.