HBV/Pregenomic RNA Increases the Stemness and Promotes the Development of HBV-Related HCC Through Reciprocal Regulation With Insulin-Like Growth Factor 2 mRNA-Binding Protein 3.

Wen-Bin DingMeng-Chao WangJian YuGang HuangDa-Peng SunLei LiuJia-Ning ZhangYuan YangHui LiuWei-Ping ZhouFu YangSheng-Xian Yuan

Published in: Hepatology (Baltimore, Md.) (2021)

In conclusion, our studies reveal a significance and mechanism of HBV-pgRNA in increasing stemness features and offer a potential prognostic marker and a therapeutic target for HBV-related HCC.

Keyphrases

hepatitis b virus
liver failure
binding protein
stem cells
epithelial mesenchymal transition
gene expression
signaling pathway
dna methylation
cancer stem cells
climate change
risk assessment