Machine-learned analysis of global and glial/opioid intersection-related DNA methylation in patients with persistent pain after breast cancer surgery.
Dario KringelMari A KaunistoEija KalsoJörn LötschPublished in: Clinical epigenetics (2019)
While clearly supporting a predictive utility of epigenetic testing, the present analysis cannot provide support for specific epigenetic modulation of persistent postoperative pain via methylation of two key genes of the glial-opioid interface.
Keyphrases
- dna methylation
- postoperative pain
- chronic pain
- genome wide
- pain management
- neuropathic pain
- gene expression
- minimally invasive
- coronary artery bypass
- copy number
- spinal cord
- spinal cord injury
- deep learning
- coronary artery disease
- surgical site infection
- percutaneous coronary intervention
- acute coronary syndrome
- young adults
- drug induced