Antagonism of Sigma-1 receptor blocks heavy alcohol drinking and associated hyperalgesia in male mice.
Sema G QuadirSean M TaninoYasmine N SamiMargaret A MinnigMalliga R IyerKenner C RicePietro CottoneValentina SabinoPublished in: Alcoholism, clinical and experimental research (2021)
These data show that Sig-1R antagonism dose-dependently reduced ethanol consumption in heavy drinking mice as well as its efficacy in reducing alcohol-induced hyperalgesia. These findings provide a foundation for the development of novel treatments for AUD and associated pain states.