Clinical Importance of Low Level of PAPP-A in First Trimester of Pregnancy - An Obstetrical Dilemma in Chromosomally Normal Fetus.
Vesna LivrinovaIgor PetrovIgor SamardziskiViktorija JovanovskaAleksandra Atanasova BoshkuIrena TodorovskaDrage DabeskiAjla ShabaniPublished in: Open access Macedonian journal of medical sciences (2019)
There is a difference in frequency of complications, in the cases with PAPP-A under 0.4 MoM, such as premature birth, preeclampsia compound with SGA fetuses versus the control group. The difference for SGA newborn and premature birth among the groups has statistical significance. The patients delivered with cesarean section were with the main indications SGA or elevated blood pressure, often occurred combined with prematurity. Apgar score and birth weight were similar in target and control group, but the newborns with a birth weight under 2500 g. were more frequent in the target group. Because these results did not show another significance among two groups, probably lower cut-off is needed, combining with another test (Doppler of uterine arteries in the first trimester, biochemical test). Presence of other diseases which could hurt placental function should be emphasised.
Keyphrases
- gestational age
- birth weight
- preterm birth
- blood pressure
- low birth weight
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- preterm infants
- peritoneal dialysis
- pregnancy outcomes
- blood flow
- type diabetes
- pregnant women
- physical activity
- heart rate
- patient reported outcomes
- adipose tissue
- weight loss
- patient reported