High-Affinity Anti-VISTA Antibody Protects against Sepsis by Inhibition of T Lymphocyte Apoptosis and Suppression of the Inflammatory Response.
Tianzhu TaoLulong BoTeng LiLongbao ShiHui ZhangBo YeYuhai XuQingqing MaXiao-Ming DengGuorong ZhangPublished in: Mediators of inflammation (2021)
The present study identified VISTA as a novel immune checkpoint in the regulation of T cell and macrophage response during sepsis. Modulation of the VISTA pathway might offer a promising opportunity in the immunotherapy for sepsis.