Chaetomugilin J Enhances Apoptosis in Human Ovarian Cancer A2780 Cells Induced by Cisplatin Through Inhibiting Pink1/Parkin Mediated Mitophagy.

Xiaoqing Hu Jiabin WangJiannan ChaiXiaoya YuYunhan ZhangYuqi FengJianchun QinHuimei Yu

Published in: OncoTargets and therapy (2020)

Chaetomugilin J combined with cisplatin inhibited pink1/parkin mediated mitophagy increased mitochondrial dysfunction in the A2780 cells and enhanced apoptosis induced by cisplatin in the ovarian cancer cell line A2780. But this process was not related to endoplasmic reticulum apoptotic pathway.

Keyphrases

cell cycle arrest
cell death
induced apoptosis
endoplasmic reticulum stress
pi k akt
endoplasmic reticulum
oxidative stress
signaling pathway
endothelial cells
drug induced