Small extracellular vesicles administered directly in the brain promote neuroprotection and decreased microglia reactivity in a stroke mouse model.
Miguel M LinoTiago RondãoArnab BanerjeeInês AiresMagda RodriguesTiago ReisAntónio SantinhaDominique FernandesDébora SerrenhoTomás SobrinoJoão Sargento-FreitasFrederico C PereiraAna Luísa CarvalhoLino S FerreiraPublished in: Nanoscale (2023)
Herein, we investigate the bioactivity of small extracellular vesicles (sEVs), focusing on their local effect in the brain. sEVs from mononuclear cells (MNCs) showed superior effects in vitro to sEVs from mesenchymal stem cells (MSCs) and were able to promote neuroprotection and decrease microglia reactivity in a stroke mouse model.
Keyphrases
- cerebral ischemia
- mouse model
- mesenchymal stem cells
- subarachnoid hemorrhage
- brain injury
- blood brain barrier
- umbilical cord
- atrial fibrillation
- induced apoptosis
- inflammatory response
- resting state
- white matter
- neuropathic pain
- functional connectivity
- cell cycle arrest
- peripheral blood
- signaling pathway
- endoplasmic reticulum stress
- stem cells
- spinal cord
- spinal cord injury
- cell proliferation
- cell therapy