Protective Effects of Zinc on Spinal Cord Injury.
Shan WenYuanlong LiXiaolei ShenZhe WangKaihua ZhangJiawei ZhangXifan MeiPublished in: Journal of molecular neuroscience : MN (2021)
Spinal cord injury is a serious disease of the central nervous system, but there is no effective treatment. And zinc is an essential nutrient for human body and participates in many physiological processes, such as immune response, homeostasis, oxidative stress, cell cycle progression, DNA replication, DNA damage repair, apoptosis, and aging. This article mainly summarizes that zinc could predict the prognosis and treat the spinal cord injury. Especially, zinc could help to inhibit inflammation, regulate autophagy, and reduce oxidative stress. However, excessive zinc will damage neurons.
Keyphrases
- oxidative stress
- spinal cord injury
- dna damage
- cell cycle
- oxide nanoparticles
- spinal cord
- immune response
- ischemia reperfusion injury
- diabetic rats
- induced apoptosis
- endothelial cells
- endoplasmic reticulum stress
- cell proliferation
- dna repair
- cell death
- inflammatory response
- physical activity
- cell cycle arrest
- pi k akt