Developing and validating Parkinson's disease subtypes and their motor and cognitive progression.
Michael A LawtonYoav Ben-ShlomoMargaret T MayFahd BaigThomas R BarberJohannes C KleinDiane M A SwallowNaveed MalekKatherine A GrossetNin BajajRoger A BarkerNigel WilliamsDavid J BurnThomas FoltynieHuw R MorrisNicholas W WoodDonald G GrossetMichele T M HuPublished in: Journal of neurology, neurosurgery, and psychiatry (2018)
We have found four novel clusters that replicated well across two independent early PD cohorts and were associated with levodopa response and motor progression rates. This has potential implications for better understanding disease pathophysiology and the relevance of patient stratification in future clinical trials.