Targeting hypercoagulation to alleviate Alzheimer's disease progression in metabolic syndrome.
Sana KhanSoumya PatiShailja SinghMohd AkhtarPiush KhareSaba KhanSadat ShafiAbul Kalam NajmiPublished in: International journal of obesity (2005) (2021)
The present paper proposes the hypothesis that hypercoagulation might amplify MetS associated insulin resistance, neuroinflammation, BBB disruption, and amyloid beta accumulation which eventually leads to AD.
Keyphrases
- insulin resistance
- metabolic syndrome
- blood brain barrier
- high fat diet
- adipose tissue
- polycystic ovary syndrome
- cognitive decline
- traumatic brain injury
- uric acid
- skeletal muscle
- lipopolysaccharide induced
- lps induced
- cancer therapy
- high fat diet induced
- type diabetes
- cerebral ischemia
- cardiovascular risk factors
- cognitive impairment
- inflammatory response
- drug delivery
- weight loss