Genetic and transcriptomic landscape of colonic diverticulosis.

Jungkyun SeoHongwei LiuKristin YoungXinruo ZhangTemitope O KekuCorbin D JonesKari E NorthRobert S SandlerAnne F Peery

Published in: Gut (2024)

Our results suggest that tissue remodelling is a primary mechanism for diverticula formation. Individuals with an increased genetic proclivity to diverticulitis exhibit a larger numbers of diverticula on colonoscopy.

Keyphrases

genome wide
single cell
copy number
rna seq
ulcerative colitis
colorectal cancer screening