Human leukocyte antigen DQ2/DQ8 positivity in women with history of stillbirth.

Mauro CozzolinoCaterina SerenaAntonino Salvatore CalabróElena SaviMarianna Pina RambaldiSerena SimeoneSerena OttanelliGiorgio MelloGiovanni RomboláGianmarco TroianoNicola NanteSilvia VannucciniFederico MecacciFelice Petraglia

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)

In women with history of term stillbirth, a significantly higher prevalence of HLA DQ2/DQ8 haplotypes has been found compared to women with previous uneventful pregnancies. In addition, HLA DQ2/DQ8 positivity was significantly associated with suboptimal fetal growth in intrauterine fetal death cases, as shown by an increased prevalence of SGA babies.

Keyphrases

celiac disease
gestational age
risk factors
endothelial cells
preterm infants
pregnancy outcomes