Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes.

Nicole KiwelerDésirée WünschMatthias WirthNisintha MahendrarajahGünter SchneiderRoland H StauberWalburgis BrennerFalk ButterOliver Holger Krämer

Published in: Journal of cancer research and clinical oncology (2020)

HDACi suppress the epithelial-mesenchymal transition (EMT) and compromise the DNA integrity of cancer cells. These data encourage further testing of HDACi against tumor cells.

Keyphrases

dna repair
epithelial mesenchymal transition
histone deacetylase
dna damage
transforming growth factor
circulating tumor
signaling pathway
dna damage response
electronic health record
cell free
single molecule
big data
machine learning
nucleic acid
artificial intelligence
circulating tumor cells